There has been considerable interest for medicinal chemist in development of a promising target for new drug development. Bisphosphonic acid and chalcone are pharmacophores having diverse biological activity. Considering this biological importance of bisphosphonic acid and chalcone nucleus, both are very good anti-inflammmatory agents. Thus it was aimed to synthesize a new target which comprises both the nucleus and screen them for anti-inflammatory activity. We have synthesized new bisphosphonic acid derivatives (PMC 103A-103D) using substituted acetophenones (4-OCH3, 2-Cl, 3-NH2, 3-NO2). The synthesized compounds were confirmed by physiochemical and spectral data. All new compounds were screened for anti-inflammatory activity. Among all synthesized compound PAM 103D shows good inhibition. New moieties contain two pharmacophore bisphosphonic acid and chalcone. Due to presence of two pharmacophore synergism in anti-inflammmatory activity is obtained. Both pharmacophore have diverse biological activity therefore in future this moiety can reveal some other biological activity.
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